Alexis Anvekar MD ABIHM
We’ve Created Something New:
A Method
for detecting
brain aging
The Problem
1 in 9
people live with Alzheimer's, a type of dementia
Every father, mother, brother or grandmother with Alzheimer's tells a tragic story that started 10-25 years before their diagnosis. During that gap, there were modifiable, treatable signs that traditional healthcare couldn't detect. By the time their dementia diagnosis was made, nearly 40% of neurons were already lost and it was too late to act.
Traditional Medicine can't detect the vague, subtle signs of brain aging until the window to act starts closing.
We can.
Our groundbreaking patent-pending System
treats in the 10-25 year window before a diagnosis is made.
Our System for detecting brain aging, the CogSpanTM Immersive System, specializes in finding the modifiable, treatable signs that precede a diagnosis of dementia by 10-25 years. Our Founder, Dr. Alexis Anvekar, calls this gap the Silent Gap of DementiaTM.
Dr. Anvekar built the first system of it's kind in the country dedicated to work in the Silent Gap of DementiaTM.
Our system tosses out the traditional ways of watching and waiting for a diagnosis before considering advanced testing and treatment. We assess your health in a backwards fashion. We start by assuming a possible future diagnosis of dementia 20 years from now, and we work backwards from there to find, sort and catagorize hundreds of data points that, while meaningless on their own, may form a pattern to provide clues as to why your brain is signaling. This is not just a doctor's visit with labs. This is an advanced system designed to monitor your brain health over time with the goal of detecting and treating causes of brain and body aging.
The Silent Gap of DementiaTM is almost always missed by traditional healthcare--not because your doctor doesn't care, but because your doctor doesn't have the tools to find it.
But we do. Introducing: The CogSpan 6-Month Immersive
TM
IS YOUR BRAIN SIGNALING?
WE ARE ALREADY LISTENING
1
Your first two hour visit is
in Pasadena or virtual with mailed assessment kit
Included evaluation:
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advanced cognitive function testing
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focused mobility testing
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comprehensive lifestyle review
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Living Domain Scoring that highlights your problem area for treatment focus.
Included testing:
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mold testing
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pesticide testing
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herbicide testing
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organic acic testing
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heavy metal testing
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plastics/parabens testing
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glyphosate testing
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other toxins
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oral microbiome testing
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hormone testing
Billed to your insurance:
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brain MRI
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suite of Alzheimer's risk tests
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brain inflammation testing
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full body audit lab testing
Optional add-on:
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Full body MRI
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GRAIL 50+ cancer screen
2
Your first six months
Our team of clinicians, The CogSpanTM Council, spends 5+ hours after your visit reviewing your 300+ collected data points.
The Council crafts your 6 month CogSpanTM Blueprint that addresses your most critical area.
Months 1-2: reduce and detox Months 3-4: targeted treatments
Months 5-6: long-term plan
Included:
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MD oversight (not AI)
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6 mo prescription management of needed hormones, GLP-1 or others prescribed by Dr. Anvekar
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2 mo supply of peptides if needed
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2 mo supply of oral supplements if needed
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2 mo supply of IV therapy if needed
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3-month check-in with repeat focused labs billed to insurance, and repeat advanced cognitive testing to monitor progress
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6-month check-in with repeat focused labs billed to insurance, repeat cognitive testing, and CogSpanTM reassessment of Living Domain Scores to prove success.
3
Your Investment
and Ours
If you value your brain health, value your ability to build your legacy, and are willing to work with us for six months, we have a promise for you.
If you don't improve your scores withing 180 days of receiving your Blueprint despite following it's plans, we will extend your program until you do improve.
If you are ready to invest in yourself, we are ready to invest in you.
Your brain is busy building your legacy right now.
A healthy brain is more creative, more efficient and doesn't power down in the evenings.
Our committment to you is to try to uncover known brain age accelerators and teach you how to improve them.
We think that this will keep your brain healthier for years to come so you can continue to build your legacy and be present enough to enjoy it.
Meet our patient, Linda, describing how our program differs from a typical doctor's examination.
THE SCIENCE IS CLEAR
The Silent Gap of DementiaTM is a 10–25 Year Window
that no one talks about.
Dementia starts decades before symptoms appear. By the time a diagnosis is made, up to 40% of neurons may already be lost. The window to act is now.
window is open
window is open
window is closing
window is closing
Age 45–50
SILENT ONSET
Amyloid plaques and neuroinflammation begin to accumulate. No symptoms. Normal labs. This stage is almost always missed.
Age 50–60
THE CRITICAL WINDOW
Cognitive edge erodes: slower recall, word-finding difficulty, mental fatigue. Symptoms are waved off as "nothings." Conventional medicine has no reason to act.
Age 60–75
PREVENTION WINDOW SHORTENS
Brain volume loss becomes measurable on MRI. Mild cognitive impairment may be clinically diagnosed. Conventional medicine may offer medications that most doctors feel don't work.
Age 75+
DIAGNOSIS
By the time dementia is diagnosed, 40% of neurons may already be lost. The window to act is closing.
40%
the lost neurons at the time of dementia diagnosis is irreversible. Your labs came back normal. Your doctor sees nothing wrong. But "normal" on standard labs doesn't mean your brain is aging optimally. CogSpanTM was built specifically to find what conventional medicine misses — in the years when it still matters.
WHO IS IT FOR?
We watch over your brain
so you can build your legacy--and enjoy it.
We built a program for people who refuse to accept decline, who are starting to have subtle changes in their brain sharpness, who have a family history of dementia, or who want root-cause data and a way to follow brain function over time--not just dementia management when it's too late to act because the window has closed.
THIS PROGRAM IS FOR:
The Executive
Leads high-stakes decisions and notices the first signs of cognitive fatigue after 5pm.
The Professional
Wants root-cause data, not symptom management and pills when it's too late to act.
The Mid-Life Woman
Concerned that her "brain fog" might be a sign of being in The Silent Gap of Dementia.
The Child
Experienced with the devastation of a parent with dementia and fearing a repeated genetic cycle.
SOUND FAMILIAR?
Many high-performing executives over the age of 45 are losing their cognitive edge — silently.
Additionally, 60% of women complain of "brain fog" with perimenopause or menopause.
Their labs are normal. Their doc says it's nothing. Is this normal aging?
Or is this the most important neurological window of their life?
1:00 pm wall
The Wall
The energy crash that didn't used to happen. You used to power through. Now you're barely managing around it.
↓ efficiency
Lost Edge
You're keeping up in meetings. You used to be three moves ahead. The gap between you and your best self is widening.
½ sec slower
Slower Recall
Names take just a half-second longer than they should. You catch yourself searching for words that used to come instantly.
0 left at 7:00 pm
Nothing Left
Your family is right there — and you have nothing left to give them. Cognitive fatigue doesn't clock out at 5pm.
"I kept thinking I was just tired, stressed, or getting older because my labs are always normal. But the CogSpanTM Immersive Program quickly uncovered several concerning issues. This is the first time I've felt like someone is really looking at my health."
COGSPANTM IMMERSIVE MEMBER, AGE 52
We don't guess.
We measure. We score. We re-measure.
Before any intervention is recommended, we conduct one of the most comprehensive intake assessments available — mapping your brain, your biology, your environment, and your body from clinically meaningful angles.
Your brain built everything you have. Let us watch over it.
BRAIN FUNCTION
Cognitive Performance Testing at Baseline and Every 6 Months
We establish your personal baseline across processing speed, working memory, attention, and executive function using validated digital cognitive assessment technology. Every intervention in your protocol is measured against this number not a feeling.
INFLAMMATION, HORMONES & NUTRITION
Neuroinflammation We quantify systemic inflammation — one of the most modifiable drivers of brain aging and a direct contributor to the synaptic dysfunction underlying brain fog.
Thyroid Function We assess thyroid health with the precision it deserves — subclinical thyroid dysfunction is dramatically underdiagnosed in perimenopausal women and is a direct, reversible cause of cognitive slowing and fatigue.
Iron & Cellular Energy We measure iron storage, a marker of cellular energy production and neurological function that is frequently low in women and rarely evaluated in the context of cognitive complaints.
Neurological Foundations We assess two nutrients foundational to myelin integrity, mood regulation, and memory formation — deficiency in either is common, consequential, and correctable.
Broad Metabolic Screen A comprehensive urinary screen provides additional signals across metabolic, inflammatory, and kidney-related pathways that targeted blood testing alone may not capture.
PHYSICAL FUNCTION
Mobility & Strength Assessment Grip strength, balance, gait quality, and functional mobility are each independent predictors of cognitive trajectory and dementia risk. Physical resilience and brain health share overlapping neurobiology — deficits identified here are among the most responsive targets for early intervention.
METABOLIC HEALTH
Blood Sugar & Insulin Regulation We assess how well your body regulates blood sugar and insulin — because insulin resistance is one of the most powerful and most overlooked drivers of cognitive decline, now referred to by some researchers as "Type 3 Diabetes."
Cardiovascular & Alzheimer's Risk We go far beyond standard cholesterol, measuring true cardiovascular particle burden and genotyping for the strongest known genetic risk factor for Alzheimer's disease — information that fundamentally changes how aggressively your neuroprotective protocol needs to be calibrated.
Methylation & Stroke Risk We test for an independent risk factor for stroke, cognitive decline, and neurodegeneration that is almost entirely correctable with targeted nutritional therapy — and almost never ordered at a standard checkup.
Kidney & Vascular Health Targeted markers give us an early window into vascular and kidney health, both of which directly affect brain blood flow and cognitive resilience.
Organ Function Baseline A broad metabolic and blood cell assessment evaluates liver and kidney function, electrolyte balance, and immune status — the biological foundation everything else is built on.
ORAL MICROBIOME
Oral Microbiome Assessment Specific oral pathogens — including bacteria that have been detected in the brains of Alzheimer's patients — are associated with systemic neuroinflammation and amyloid accumulation according to science. We assess your oral microbiome to identify pathogenic bacterial overgrowth that may be silently driving cognitive symptoms from the inside of your mouth.
ENVIRONMENTAL TOXIN BURDEN
Mold & Mycotoxin Exposure We test for a panel of clinically significant mycotoxins — directly linked to progressive brain fog, memory loss, and neuroinflammation — that most physicians never consider. Many patients have no idea their home or workplace is the source of their cognitive symptoms.
Environmental Chemical Exposure We screen for a broad range of neurotoxic chemical exposures, with particular attention to compounds that actively interfere with estrogen signaling in the brain — compounding the hormonal depletion of menopause at the cellular level.
Mitochondrial & Detox Function A metabolic profiling panel reveals how your body's detoxification pathways, mitochondrial energy production, and neurotransmitter metabolism are performing under toxic load — showing us not just what toxins are present, but what they are doing to your biology.
CARDIOVASCULAR & AUTONOMIC FUNCTION
Orthostatic Heart Rate Response We measure your heart rate at rest and one minute after standing — a simple but powerful test of how well your autonomic nervous system delivers blood to your brain. A dysregulated response here is a direct, measurable, and frequently missed cause of cognitive impairment.
Resting Vitals Blood pressure, heart rate, oxygen saturation, respiratory rate, and temperature establish your cardiovascular baseline and frequently reveal patterns that more sophisticated testing alone would miss.
61
COGSPANTM SCORE
Initial assessment
AN EXAMPLE
His labs were normal.
His brain wasn't.
Mark, 52, is a senior executive who'd been hitting a hard wall every day at 1pm — a cognitive crash that didn't used to happen. By evening he had nothing left. His doctor ran every standard lab. All normal. He was told it was nothing--just stress.
His CogSpanTM Immersive Assessment told a different story. Score: 61. His primary brain aging accelerator was identified — mitochondrial dysfunction. Not a single routine lab caught this. Six months into his protocol, his score is 74 and his cognitive testing shows improvement. He is now finishing his days sharp.
He will remain in our program to get re-assessed every 6 months. We will watch over his brain so he can continue to build --and enjoy--his legacy.
300+
Data points assessed
10
Living Domains evaluated
6 mos
Protocol · Score proven
THE REAL PROMISE
We are here to watch over your brain
so you can build and enjoy your legacy.
Energy for Your Family
Finishing a demanding day and still walking through the door with something left for the people who matter most.
Physical Presence
Picking up your grandchild without thinking twice. Not falling. Moving through life with strength and confidence.
Still Building at 70, Still Sharp at 90
Creating, leading, and contributing at full capacity — not just surviving the decades ahead.
Legacy Fully Experienced
Walking down the aisle at your great-granddaughter's wedding — present, clear, and recognizing every beautiful detail.
"My patients fear Dementia more than any other diagnosis. This is the first program dedicated to treating it decades before it starts. "
ALEXIS ANVEKAR MD, THE LIVING METHOD
MEET THE FOUNDER
Alexis Anvekar
MD, ABIHM
FOUNDER · THE LIVING METHOD™
Throughout my 25-year career, I've noticed an increase in my patients reporting vague symptoms and they always have normal labs. A biochemist by training, I set out to build a program that can pick up patterns of borderline labs, lifestyle measurements and other important data points that we don't measure in traditional medicine, including mobility assessments and labs not covered by insurance.
What I built reveals a hidden and treatable pattern that can be targeted and re-measured after a three-phase, six month personalized protocol.
What's more, any doctor in the country can run my program without any board certification in longevity medicine--which is 99% of the physicians in the US. Thus my patent-pending program has the capability to bring real healthcare to people regardless of their access to longevity centers.
This is a step to a healthier you. This is true healthcare.
CREDENTIALS
MD, ABIHM — Board Certified in Integrative & Holistic Medicine · Board Certified in Internal Medicine, National Board of Physicians & Surgeons
INNOVATION
Founder and Creator of Living Method and its patent-pending CogSpanTM Immersive Program built to detect The Silent Gap of DementiaTM
SPECIALTY
Cognitive longevity, precision diagnostics, brain performance, Concierge Primary Care
LOCATION
The Living Method
445 S Fair Oaks Ave
Pasadena, California
91105
Dr. Alexis Anvekar was raised in Salt Lake City, Utah. Although starting college at age 17 as a homeless student, she was able to graduate with honors from both UC San Diego and USC School of Medicine, where she was additionally the only person in her medical school to be awarded USC's highest honor.
Dr. Anvekar paid for college by working full-time and by receiving leadership scholarships for her leadership roles throughout college and medical school.
Her roles included Southern California Vice-President, Los Angeles President, National Vice-President, Editor-in-Chief of college newspaper, Co-Editor-in-Chief of medical school newspaper, Co-Founder of Student Organization for the Medical Awareness of AIDS, and creator of a curriculum in USC Medical School that continued decades after she graduated, Delegate for American Medical Association (AMA) and American Medical Women's Association (AMWA).
Dr. Anvekar received a national leadership award with AMWA given to the most promising female physician-in-training in the country.
As a senior at the medical school, she was invited along with the top 0.01% of graduating seniors to complete a coveted leadership fellowship called the USC Presidential Fellowship ran by USC's Marshall School of Business.
When in residency, Dr. Anvekar met regularly with politicians in Los Angeles, Sacramento, and Washington, D.C. as an ambassador of the LAC+USC Medical Center and ally of the Angelinos in all walks of life served by LAC+USC.
She has been practicing since 2001 and was amongst the first in California to start a personalized type of healthcare service that mirrors the old ways of practicing medicine, now known as concierge medicine.
She chose to practice in Pasadena and started her own concierge practice in 2004 and is still practicing concierge medicine with Living Method.
Awards include Top Docs, Most Compassionate Doctor Award (given to top 3% nationwide physicians), Patient's Choice Award (given to top 6% nationwide physicians), America's Most Honored Professionals Award, LA Magazine's Top Doctors Award, Pasadena Magazine Top Docs Award, America's Best Physicians Award and Who's Who Among Women Entrepreneurs.
Being active in her community and fostering a love for charity in her children is a priority to Dr. Anvekar. She Co-Founded a group called "Kids for Change." This is a group of amazing local families who introduce their children to charity by purchasing, cooking and serving meals to the 50+ homeless men, women and children of the Union Station Homeless Services Family Center one dinner a month since 2010 until the children all left for college.
In an effort to do her part in furthering science education, she served as Chair of the Science Fair at her local elementary and middle schools from 2011 to 2017 with some students advancing to national competitions. In 2009 she founded Wild 4 Science, an after school enrichment program aimed at fostering a lifelong love for science in young children. Dr. Anvekar believes that by introducing children to the fun and creativity in science at an early age, they are more likely to enjoy and succeed in science in the future.
Dr. Anvekar loves spending time with her family and friends. She enjoys photography as her primary hobby and maintains roots in the mountains of her home state, Utah.
Meet The Team
LET US LOOK AFTER YOU BRAIN
Enrollment is intentionally limited to maintain clinical quality.
HSA/FSA eligible
Financing available
Insurance billing where applicable
Letter of Medical Necessity provided