CogSpan™ IS THE LIFESPAN
OF YOUR
HEALTHY BRAIN
AND
YOUR PROMISE
TO YOUR FAMILY
1 in 9
people over age 65 live with Alzheimer's Dementia in the U.S.
Their brains have been sending SOS signals for decades but there has been no way to listen to the signals.
UNTIL NOW
Every father, mother, sister or grandfather with Alzheimer's tells a tragic story that started 10-25 years before their diagnosis. Our founder Dr. Alexis Anvekar calls this 10-25 year gap The Silent Gap™. During this gap, there were signals of brain inflammation that traditional healthcare couldn't detect. By the time their dementia diagnosis was made, 30-60% of neurons were already lost and the treatment window in The Silent Gap™ had likely closed.
Traditional Medicine can't detect the vague, subtle signs of brain aging until the window to act starts closing.
We can.
Our groundbreaking patent-pending System was built to detect and treat The Silent Gap™
Our System for detecting brain aging, the CogSpan ™ System, specializes in finding the modifiable, treatable signs that may precede a diagnosis of dementia by 10-25 years - The Silent Gap™.
"My patients fear Dementia more than any other diagnosis. CogSpan™ is the first program dedicated to The Silent Gap™."
ALEXIS ANVEKAR MD, THE LIVING METHOD
Why Get a
Living Method CogSpan™ Physical
even when you don't feel sick?
Measure your health while it is still yours to shape.
Many of the changes that eventually lead to diabetes, cardiovascular disease, cognitive decline, frailty and other age-related conditions begin years or decades before a diagnosis can be made.
Don’t wait for disease to show up in your health story. Prevent it in the earliest stages.
We call this the Silent Gap™: the window between feeling healthy and developing recognizable disease. During this time:
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Laboratory results may remain inside broad “normal” ranges
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Insulin resistance may begin before glucose becomes abnormal
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Muscle and cardiovascular fitness may decline before daily function changes
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Cognitive performance may shift before symptoms become obvious
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Inflammatory and metabolic patterns may emerge gradually
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Sleep, stress and recovery may begin influencing multiple body systems
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Several small changes may matter more together than any one result does alone
The goal of the Living Method Physical is not to diagnose disease that is not present. It is to look for patterns, trends and areas moving away from optimal health while there is still time to pay attention.
Normal is not always good enough:
A laboratory value may be technically normal while still becoming less favorable over time.
A single result may seem unimportant on its own but become more meaningful when considered alongside sleep, cognition, waist circumference, blood pressure, physical performance, family history and other measurement changes. Our model is designed to recognize these relationships.
More than 160 health data points:
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Your one-day assessment combines information from several areas of health.
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Detailed health questionnaire
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More than 100 questionnaire variables explore:
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Personal and family medical history
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Cognitive concerns
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Metabolic health
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Sleep quality and sleep-disorder risk
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Cardiovascular risk
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Physical activity and recovery
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Nutrition and lifestyle
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Stress and adverse childhood experiences
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Hormonal symptoms
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Energy and cellular health
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Environmental exposures
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Purpose, connection and resilience
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Preventive-health engagement
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Readiness for change
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Advanced blood and urine testing
Your laboratory assessment evaluates major areas associated with long-term health, including:
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Glucose and insulin regulation
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Cholesterol and cardiovascular riskInflammatory patterns
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Immune-cell balance
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Kidney and liver health
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Thyroid function
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Nutrient status
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Hormonal factors when clinically appropriateUrine and early kidney-health markers
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Testing may be individualized according to age, sex, symptoms, medical history and current medications.
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Tier 2 and Tier 3 testing includes advanced neuroinflammation and environmental toxin assessments.
Neurocognitive testing objectively assesses important areas of cognitive performance, including:
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Memory
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Attention
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Processing speed
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Executive function
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Cognitive flexibility
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Anxiety
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Depression
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PTSD
This creates a cognitive baseline that can be compared with future results. BrainCheck is a screening and monitoring tool and does not independently diagnose dementia or another neurologic condition.
Physical and functional measurements including:
Your assessment evaluates important indicators of cardiovascular and physical reserve.
A Living Method nurse practitioner completes your physical examination, medication and supplement review, and preventive-health review in advance of your results consultation with Dr. Anvekar. An EKG is performed when clinically indicated.
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Blood pressure
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Resting heart rate
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Oxygen saturation
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Waist measurement
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Heart-rate response to standing
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Strength
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Walking speed
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Lower-body endurance
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Mobility
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Balance
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Recovery
The Living Method patent-pending mathematical model precisely calculates every data point and is not available anywhere else:
Most physicals present each result separately and you leave with a stack of labs.
The Living Method examines how the results work together.
Each data point moves through a proprietary mathematical process:
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The measurement or response is evaluated.
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An evidence-informed coefficient reflects its relative importance to long-term health.
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The result is standardized against appropriate reference information.
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It is integrated with the other data contributing to the same health domain.
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The process repeats with every single data point across the complete assessment.
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Ten Living Method Domain Scores and one overall score is produced to guide your annual health goals and compare to future Domain Scores to keep your health on track.
Your 10 Living Method Domain Scores:
You receive concrete scores across:
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Brain
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Metabolic
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Sleep
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Cardiovascular
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Physical Function
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Inflammation
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Hormonal Health
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Mitochondrial and Oxidative Stress
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Purpose and Reserve
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Risk and Health Engagement
Follow your health—not just your test results
A single assessment shows where you stand today. Repeating the Living Method Physical annually allows you to see:
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Which scores are improving
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Which scores are stable
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Which areas are beginning to change
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Whether your health efforts are producing measurable progress
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Where additional evaluation may be worth considering
Your first assessment creates the baseline.
Each future assessment adds another point to your personal health trajectory. That makes the Living Method Physical especially valuable for younger, healthy adults: you establish your baseline before age, illness or medication significantly changes it.
Your results meeting with Dr. Anvekar will review:
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Your 10 Living Method Domain Scores
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Biological-age estimate
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Cognitive baseline
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Laboratory patterns
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Physical-performance results
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Areas that appear strong
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Areas that may deserve attention during the coming year
This tier provides a comprehensive scorecard and physician review. It does not include a personalized treatment blueprint or ongoing medical-management program.
-- THE COGSPAN™ SYSTEM --
One day to measure your health.
Ten scores to guide what comes next.
Tier 1 Essentials
Living Method
COGSPAN™
Physical
$1,495 for the:
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Proactive
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Under age 50
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No symptoms
You don’t have to feel sick to discover that your health is beginning to change.
The Living Method Physical is designed for healthy, proactive adults who want to understand what is happening beneath the surface—years before abnormal results, persistent symptoms or a diagnosis tell the story.
In one coordinated assessment day, we collect more than 160 health data points through advanced bloodwork (billed to your insurance), cognitive testing, a comprehensive health questionnaire, physical examination, and measurements of cardiovascular and functional health.
But collecting data is only the beginning.
The Living Method’s proprietary, patent-pending mathematical model evaluates every data point, weighs it according to its importance in longevity science, standardizes it against relevant clinical and population data, and integrates it into your 10 Living Method Domain Scores.
The result is not another folder of laboratory results. It is a concrete, numerical baseline you can follow year after year.
Tier 2 Advanced
Living Method
COGSPAN™
Physical
$3,495 for the:
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Proactive
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Over age 45
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Might be in The Silent Gap™
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Family History of Dementia
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Increased risk of dementia
Go beyond your foundational scores with more than 100 additional advanced biomarkers including neuroinflammation markers, fitness testing, body composition imaging, screening for 50+ cancers, and a comprehensive panel of environmental exposures.
The Advanced Physical includes everything in the Living Method Physical, plus VO₂ max, DEXA body composition and bone density, Galleri® multi-cancer early detection testing, comprehensive environmental and metabolic testing, and physician-selected imaging when medically appropriate billed to your insurance.
The advanced testing returns about a month after submission, so we will require you to submit blood and urine testing 4-5 weeks in advance of your assessment day.
Additionally, diet restrictions will need to be in place for the four days before your urine collection.
One assessment day. Ten proprietary scores. A deeper investigation into the signals shaping your health.
Tier 3 Premier
Living Method
COGSPAN™
Physical
$5,995+ for the:
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Proactive, or
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Over age 50, or
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Chronic disease, or
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In The Silent Gap™
Our most advanced one-day assessment—everything in the Advanced tier and physician-selected longevity and regenerative therapies when medically appropriate.
The Premier Physical includes everything in the Advanced Physical, followed by a physician-directed treatment experience designed around your history, examination, goals and medical eligibility.
Your treatment experience may include an exosome IV infusion, stem cell treatments for hair loss, joint pain, neurological conditions, lung or heart conditions, inflammatory conditions. Your treatment may also include an NAD+ infusion, advanced high dose IV therapy infusion, and/or physician-selected peptides when appropriate. You may also receive other testing or training services offered by Living Method. These therapies are customized for you by Dr. Anvekar to give you the most advanced longevity physical available with cutting-edge regenerative medicine therapies offered at The Living Method. Therapies such as peptides, stem cell treatments, IV Therapy, red light therapy may not be FDA approved for your condition.
-- THE COGSPAN™ SYSTEM --
Our testing is comprehensive
BRAIN FUNCTION TESTING (all Tiers)
Cognitive Performance Testing
We establish your personal cognitive baseline with objective, computerized testing that measures overall memory, working memory, processing speed, attention, executive function, and reaction time. Regular testing helps detect subtle cognitive changes long before they become clinically apparent, supporting early dementia risk assessment and monitoring for conditions associated with brain inflammation. We also evaluate anxiety, depression, PTSD, and Adverse Childhood Experiences (ACEs)—all of which can significantly influence cognitive health, inflammation, and healthy aging. Most importantly, every intervention in your personalized program is measured against objective data, not just how you feel.
HEART AND BLOOD VESSEL FUNCTION
Heart Rate Response
We measure your heart rate and blood pressure at rest and after standing to assess how well your autonomic nervous system maintains blood flow to the brain. An abnormal response may indicate autonomic dysfunction or impaired vascular regulation—common but often overlooked causes of dizziness, fatigue, brain fog, exercise intolerance, and cognitive decline.
Resting Vital Signs
Blood pressure, resting heart rate, oxygen saturation, respiratory rate, and temperature establish your cardiovascular baseline and provide important insight into your heart, lung, and overall health. These simple measurements help identify early health concerns and serve as objective benchmarks to track your progress over time.
INFLAMMATION, HORMONES & NUTRITION (All tiers)
Brain Inflammation
We measure key markers of inflammation because chronic inflammation can damage brain cells, accelerate brain aging, and contribute to brain fog, memory problems, and an increased risk of cognitive decline. Detecting inflammation early allows us to target one of the most treatable drivers of long-term brain health.
Hormone & Thyroid Function
We evaluate hormones and thyroid function because even mild imbalances can contribute to fatigue, brain fog, slowed thinking, mood changes, and memory problems. These subtle abnormalities are often missed during routine medical evaluations but are among the most treatable causes of cognitive dysfunction.
Iron & Cellular Energy
Iron is essential for carrying oxygen, producing cellular energy, and supporting healthy brain function. We measure your iron stores because both low and high iron levels can contribute to fatigue, brain fog, poor concentration, and reduced physical performance.
Neurological Foundations
We measure essential nutrients that support healthy brain function, nerve protection, memory, mood, and energy production. Deficiencies are common, can contribute to brain fog and cognitive decline, and are often easily corrected with targeted nutrition or supplementation.
ADVANCED TESTING & TREATMENT OPTIONS
Add-on suite of testing
Your initial assessment is designed to identify the most important opportunities to improve your health. Based on your results, we may recommend additional testing or targeted therapies to further evaluate and optimize specific areas of concern. These may include continuous glucose monitoring (CGM), total body or brain MRI, oral microbiome analysis, home sleep testing, VO₂ max testing, total body bone and muscle composition, resting metabolic rate testing, GRAIL cancer screening for 50+ cancers, or referrals for specialists for additional as-needed testing. Not all treatments are available virtually.
Add-on suite of treatments may include evidence-based supplement protocols, prescriptions for hormones or medications, IV nutrient therapy, peptides, regenerative medicine treatments including stem cell and exosome therapy, red light therapy, fitness training, high/low oxygen training (IHHT), red light therapy or additional consultations with our providers, fitness director, chiropractor or menopause and health coach. Not all treatments are available virtually.
ENVIRONMENTAL TOXIN BURDEN (Advanced and Premier Tiers)
Mold & Mycotoxin Exposure
We test for a panel of clinically significant mycotoxins — directly linked to progressive brain fog, memory loss, and neuroinflammation — that most physicians never consider. Many patients have no idea their home or workplace is the source of their cognitive symptoms.
Environmental Chemical Exposure
We test for environmental chemicals that can disrupt hormones, increase inflammation, and affect brain health. Identifying these hidden exposures allows us to reduce your toxic burden and create a personalized plan to support healthier aging and better cognitive function.
Your Cells' Power & Detox System
Your cells rely on tiny "energy factories," called mitochondria, to produce the energy needed for your brain, muscles, and every organ to function properly. Advanced testing evaluates how efficiently your body produces energy, processes brain chemicals, and removes toxins. These results help us understand how environmental exposures may be affecting your health.
Microplastics & Forever Chemicals
Emerging research suggests that microscopic plastic particles can enter the bloodstream and may reach the brain by crossing the blood-brain barrier. Because the brain has limited mechanisms for clearing many persistent environmental contaminants, these particles may accumulate over time and contribute to brain inflammation. Our comprehensive environmental assessment evaluates exposure to plastics, PFAS ("forever chemicals"), heavy metals, and other toxins to identify modifiable risks and develop personalized strategies that support brain health, healthy aging, and long-term cognitive resilience.
MOBILITY AND STRENGTH
Mobility & Strength Assessment Physical function is one of the strongest predictors of healthy aging, independence, and long-term brain health. We evaluate grip strength, balance, walking speed and quality, the quality of your mobility, lower-body strength, and fall risk using objective performance testing offered virtually with a mailed assessment kit, or in-person in Pasadena, CA.
ADVANCED BRAIN INFLAMMATION LABS (Advanced and Premier Tiers)
Advanced Neurodegeneration Biomarkers
When clinically appropriate, we offer advanced blood testing for amyloid beta 42/40 ratio (Aβ42/40), phosphorylated tau-217 (p-tau217), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP). These cutting-edge biomarkers can help detect early Alzheimer's disease pathology, neuronal injury, and neuroinflammation—often years before symptoms become apparent—allowing for more personalized risk assessment and earlier intervention.
Blood Sugar & Insulin Regulation
We assess how well your body regulates blood sugar and insulin because insulin resistance is one of the most powerful—and often overlooked—causes of brain aging.
Stroke & Brain Health Risk
We measure a blood marker linked to stroke, memory loss, and dementia. High levels often indicate your body's natural repair system isn't working efficiently and can frequently be improved with targeted nutrition and vitamin therapy.
Kidney Health
Targeted biomarkers provide an early window into kidney and vascular health, both of which directly influence brain blood flow, toxin clearance, and long-term cognitive resilience.
Organ Function Baseline
A comprehensive metabolic panel and blood cell analysis evaluates liver and kidney function, electrolyte balance, immune health, and overall metabolic resilience—the biological foundation upon which every longevity intervention is built.
YOUR LOCAL AIR AND WATER QUALITY (Advanced and Premier Tiers)
Your Air and Water Quality is important
The quality of the air you breathe and the water you drink directly affects every organ in your body. Chronic exposure to pollutants and contaminants can increase inflammation, impair immune function, damage the brain and heart, and accelerate aging.
-- THE COGSPAN™ SYSTEM --
What to Expect
Virtually from your own Home
Mailed Assessment Kit containing examination equipment
Zoom Visit Assessment with Clinician - not all Tier 2 Advanced and Tier 3 Premier services can be performed off-site.
Tier 1 - Essentials
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3 weeks ahead:
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Fasting blood draw 3 weeks prior to vist
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Day of visit:
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come in comfortable clothing ready to move
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Tier 2 - Advanced and Tier 3 - Premium Tiers:
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4 weeks ahead:
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4 days of diet restrictions to prepare for environmental testing suite
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collect overnight urine sample and mail to lab
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3 weeks ahead:
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Fasting blood draw
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Day of visit:
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wear comfortable clothing ready to move
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testing links will be emailed to you
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zoom link for your movement tests with our staff will be emailed to you
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In-Person at our Pasadena Facility
In-Person
Assessment
Tier 1 - Essentials
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3 weeks ahead:
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Fasting blood draw 3 weeks prior to vist
-
-
Day of visit:
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come in comfortable clothing ready to move
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Tier 2 - Advanced and Tier 3 - Premium Tiers:
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4 weeks ahead:
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4 days of diet restrictions to prepare for environmental testing suite
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collect overnight urine sample and mail to lab
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3 weeks ahead:
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Fasting blood draw
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Day of visit:
-
come in comfortable clothing ready to move
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What
We Do
PHASE 1 | DETOX
Reduce Inflammatory Burden
The first step is identifying and reducing factors that may contribute to chronic inflammation and impaired brain function. Depending on your evaluation, your plan may include environmental toxin reduction strategies, targeted nutritional supplements, physician-supervised detoxification protocols, IV nutrient therapy, dietary changes through the My Living Eats™ app, and treatment of underlying conditions such as insulin resistance, sleep disorders, hormone imbalance, chronic infections, or oral inflammation. Follow-up cognitive testing helps determine whether these interventions are improving.
PHASE 2 | RESTORE
Rebuild Brain Health
Once inflammatory drivers are being addressed, treatment shifts toward restoring the biological systems that support healthy brain function. Your personalized program may include optimization of metabolic health, sleep, nutrition, hormones, cardiovascular health, mitochondrial function, and physical fitness, along with evidence-based supplementation and prescription therapies when appropriate. Additional imaging, specialty testing, or referral to collaborating specialists may be recommended based on your individual findings. In this phase, we will consider adding IV therapy and peptide therapies if appropriate. Several investigational therapies are being studied for their potential role in supporting brain health. Semax and Selank are synthetic peptides that have been used outside of the U.S. for cognitive impairment, anxiety disorders, recovery after stroke, and other neurological conditions.
Although early clinical studies have shown encouraging findings, these peptides are not approved by the U.S. Food and Drug Administration for the treatment of neurological disease, and additional high-quality clinical trials are needed to establish their safety and effectiveness.
PHASE 3 | REPLENISH
Support Long-Term Brain Resilience
Once in Phase 3, we will retest your cognitive function to ensure that your detox and restoration pathways are cleared and functioning better. For select patients, we may recommend Stem cell-based therapies and extracellular vesicles (often called exosomes) that are also active areas of research. Early laboratory studies and small human trials suggest these therapies may influence neuroinflammation, immune signaling, and tissue repair. However, they remain investigational for neurodegenerative diseases, and larger randomized clinical trials are needed before they can be considered established treatments.
At the end of six months, we will recommend a repeat assessment to compare scores to ensure that goals have been met. Afterwards, we will recommend cognitive testing alone or with a full repeat assessment every 6-12 months long term to continue to keep an eye on your brain health.
How We
Compare
This data is from published sources and is subject to change
ARE YOU READY?
The best time to start was ten years ago. The second best time is now.
Join our next Assessment Date
HSA/FSA eligible
Financing available
Insurance billing where applicable
Letter of Medical Necessity provided